Paroxetine HCl Hemihydrate
Paroxetine HCl Hemihydrate
CAS: 110429-35-1
Molecular Formula: C19H17ClD4FNO3
Paroxetine HCl Hemihydrate - Names and Identifiers
| Name | Paroxetine HCl Hemihydrate |
| Synonyms | PAROXETINE-D4 HCL Paroxetine HCl Hemihydrate Paroxetine-D4 hydrochloride Paroxetine Hydrochloride (350 mg) paroxetine hydrochloride Hemihydrate PAROXETINE-D4 HCL kf-yuwen(at)kf-chem.com (-)-(3S,4R)-PAROXETINE HYDROCHLORIDE HEMIHYDRATE 1,3-benzodioxol-5-yl-[4-(4-fluorophenyl)-3-piperidinyl]methanol hydrochloride (3s-trans)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride Hemihydrate |
| CAS | 110429-35-1 |
| EINECS | 000-000-0 |
| InChI | InChI=1/C19H20FNO3.ClH/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;/h1-6,9,14,17,21H,7-8,10-12H2;1H/t14?,17-;/m0./s1 |
Paroxetine HCl Hemihydrate - Physico-chemical Properties
| Molecular Formula | C19H17ClD4FNO3 |
| Molar Mass | 369.85 |
| Melting Point | 121-131 C |
| Boling Point | 451.7℃ at 760mmHg |
| Solubility | Slightly soluble in water, freely soluble in methanol, sparingly soluble in ethanol (96 per cent) and in methylene chloride. |
| Appearance | powder |
| Color | white |
| Maximum wavelength(λmax) | 292nm(H2O)(lit.) |
| Merck | 14,7043 |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| In vitro study | Paroxetine (1 μM and 10 μM) distinctly restrains T cell migration induced by CX3CL1 through inhibiting GRK2. Paroxetine inhibits GRK2 induced activation of ERK. Paroxetine (10 μM) reduces pro-inflammatory cytokines in LPS-stimulated BV2 cells. Paroxetine (0-5 μM) leads to a dose-dependent inhibition on LPS-induced production of TNF-α and IL-1β in BV2 cells. Paroxetine also inhibits lipopolysaccharide (LPS)-induced nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in BV2 cells. Paroxetine (5 μM) blocks LPS-induced JNK activation and attenuates baseline ERK1/2 activity in BV2 cells. Paroxetine relieves microglia-mediated neurotoxicity, and suppresses LPS-stimulated pro-inflammatory cytokines and NO in primary microglial cells. |
| In vivo study | Paroxetine treatment obviously attenuates the symptoms of CIA rats. Paroxetine treatment clearly prevents the histological damage of joints and alleviates T cells infiltration into synovial tissue. Paroxetine reveals a strong effect on inhibiting CX3CL1 production in synovial tissues. Paroxetine (20 mg/kg/day) reduces the myocyte cross-sectional area in rat and ROS formation in the remote myocardium. Paroxetine reduces the susceptibility to ventricular tachycardia. Paroxetine treatment following MI decreases LV remodeling and susceptibility to arrhythmias, probably by reducing ROS formation. In CCI paroxetine-treated group, paroxetine (10 mg/kg, i.p.) produces hyperalgesia at days 7 and 10 (P<0.01), but a decrease in pain behavior is seen at day 14. Moreover, paroxetine (10 mg/kg) significantly attenuates tactile hypersensitivity when compared to CCI vehicle-treated group. |
Paroxetine HCl Hemihydrate - Risk and Safety
| Risk Codes | R11 - Highly Flammable R34 - Causes burns R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 - Wear suitable protective clothing. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| RTECS | TM4569320 |
| HS Code | 29349990 |
| Hazard Class | IRRITANT |
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Product Name: Paroxetine hydrochloride hemihydrate Visit Supplier Webpage Request for quotationCAS: 110429-35-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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